|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
We showed that SNPs from GCK, G6PC2 and MTNR1B modulated the fasting glucose levels in the normoglycaemic population while SNPs from G6PC2 and GCKR was associated with type 2 diabetes.
|
20668700 |
2010 |
|
Diabetes Mellitus
|
0.200 |
Biomarker
|
group |
BEFREE |
We propose that GCKR is a susceptibility gene in Japanese families with clustered diabetes.
|
21236713 |
2011 |
|
Diabetes
|
0.180 |
Biomarker
|
disease |
BEFREE |
We propose that GCKR is a susceptibility gene in Japanese families with clustered diabetes.
|
21236713 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether a 1-year intensive lifestyle intervention (ILI) for weight loss would avert the unfavorable cardiometabolic effects associated with GCKR Leu446Pro when compared with a diabetes mellitus support and education arm in overweight/obese individuals with type 2 diabetes mellitus with triglyceride (n=3214) and CRP (n=1411) data participating in a randomized lifestyle intervention study for weight loss, Action for Health in Diabetes Mellitus (Look AHEAD).
|
26578543 |
2016 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We have demonstrated a significant interaction between the GCKR rs1260326-P446L polymorphism and plasma n-3 PUFA levels modulating insulin resistance and inflammatory markers in MetS subjects.
|
21674002 |
2011 |
|
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We genotyped the two GCKR SNP in 3346 DPP participants and evaluated association with progression to diabetes and both baseline levels and changes in triglycerides, homeostasis model assessment of insulin resistance (HOMA-IR), oral disposition index, and inflammatory markers along with their interactions with DPP interventions.
|
21525158 |
2011 |
|
Diabetes
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
We genotyped the two GCKR SNP in 3346 DPP participants and evaluated association with progression to diabetes and both baseline levels and changes in triglycerides, homeostasis model assessment of insulin resistance (HOMA-IR), oral disposition index, and inflammatory markers along with their interactions with DPP interventions.
|
21525158 |
2011 |
|
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We found that: (i) genotypes, including those of APOA5 S19W, APOA5 -1131T > C, APOE, GCKR, TRIB1 and TBL2/MLXIPL, were significantly associated with severe HTG; (ii) odds ratios for these genetic variables were significant in both univariate and multivariate regression analyses, irrespective of the presence or absence of diabetes or obesity; (iii) a significant fraction-about one-quarter-of the explained variation in disease status was associated with these genotypes.
|
18596051 |
2008 |
|
Diabetes
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
We found that: (i) genotypes, including those of APOA5 S19W, APOA5 -1131T > C, APOE, GCKR, TRIB1 and TBL2/MLXIPL, were significantly associated with severe HTG; (ii) odds ratios for these genetic variables were significant in both univariate and multivariate regression analyses, irrespective of the presence or absence of diabetes or obesity; (iii) a significant fraction-about one-quarter-of the explained variation in disease status was associated with these genotypes.
|
18596051 |
2008 |
|
Steatohepatitis
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
We determined the frequency of PNPLA3 (rs738409), CSPG3/NCAN (rs2228603), GCKR (rs780094), PPP1R3B (rs4240624), TM6SF (rs8542926), LYPLAL1 (rs12137855) and MBOAT7 (rs626283) by RT-PCR in 117 HIV-positive patients on cART and stratified participants based on their "controlled attenuation parameter" (CAP) into probable (CAP: 215-300 dB/m) and definite (CAP >300 dB/m) hepatic steatosis.
|
28594920 |
2017 |
|
Fatty Liver
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
We determined the frequency of PNPLA3 (rs738409), CSPG3/NCAN (rs2228603), GCKR (rs780094), PPP1R3B (rs4240624), TM6SF (rs8542926), LYPLAL1 (rs12137855) and MBOAT7 (rs626283) by RT-PCR in 117 HIV-positive patients on cART and stratified participants based on their "controlled attenuation parameter" (CAP) into probable (CAP: 215-300 dB/m) and definite (CAP >300 dB/m) hepatic steatosis.
|
28594920 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
We demonstrate that Sirt2-dependent GKRP deacetylation improves impaired HGU and suggest that it may be a therapeutic target for type 2 diabetes.
|
29296001 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
CTD_human |
We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes.
|
20081858 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes.
|
20081858 |
2010 |
|
Steatohepatitis
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
We aimed to assess whether GCKR rs780094 C→T SNP influences the expression of steatosis, lobular inflammation and fibrosis in NAFLD patients, after correction for PNPLA3 genotype.
|
24498332 |
2014 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Variants of the glucokinase regulator (GCKR) gene are associated with metabolic syndrome (MetS).
|
26799416 |
2016 |
|
Fatty Liver
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Variant in glucokinase regulatory protein (GCKR), associated with lipid and glucose traits, has been suggested to affect fatty liver infiltration.
|
24498332 |
2014 |
|
Glomerular Filtration Rate
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate.
|
23535967 |
2013 |
|
Maturity onset diabetes mellitus in young
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Two of these loci (GCKR and HNF1A) are suspected or known to be associated with maturity-onset diabetes of the young, one is a gene-desert region on 12q23.2, and the remaining four loci are in or near the leptin receptor protein gene, the apolipoprotein E gene, the interleukin-6 receptor protein gene, or the CRP gene itself.
|
18439548 |
2008 |
|
Glomerular Filtration Rate
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.
|
30604766 |
2019 |
|
Glomerular Filtration Rate
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity.
|
27588450 |
2016 |
|
insulinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
To study the effects of GKRP expression levels in the subcellular localization of GK, we used insulinoma 832/13 cells and hypothalamic tanycytes to overexpress the tanycytic sequences of <i>Gckr</i>.
|
30983961 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To investigate this inconsistency, we performed a meta-analysis of 19 studies involving a total of 298,977 subjects for GCKR rs780094 to evaluate its effect on genetic susceptibility for T2D.
|
23307301 |
2013 |
|
Hypertriglyceridemia
|
0.490 |
GeneticVariation
|
phenotype |
GWASCAT |
Through GWAS, we identified common variants in APOA5, GCKR, LPL and APOB associated with HTG.
|
20657596 |
2010 |
|
Hypertriglyceridemia
|
0.490 |
Biomarker
|
phenotype |
CTD_human |
Through GWAS, we identified common variants in APOA5, GCKR, LPL and APOB associated with HTG.
|
20657596 |
2010 |